Stimuli-responsive chemistries and materials are programmed to react in thepresence of changes in their surrounding environment to produce a measurablle output, such as a change in shape, release of active moiety, assembly, or mechanical output. Examples of stimuli can include electric field, magnetic, thermal, light,** mechanical, pH, ROS, enzyme, glucose, and others (e.g. salts, solvents, electron beam). We will discuss the properties, design, and applications of these stimuli-responsive materials that have aided the development of active-, as opposed to passive, biomaterials for the advancement of biomedicine. This 2-unit course makes use of modern scientific literature to discuss the topics at hand.